2025

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2024

Case report: Cerebrospinal fluid neutrophilic pleocytosis upon intrathecal triamcinolone injection

Thanos Tsaktanis, Jenny Stritzelberger, Vi Tuong Daniel To, Martin Uhl, Stefan Schwab, Dieter Heuss, Veit Rothhammer

Front Neurol. 2024. doi: 10.3389/fneur.2024.1372266

Expression of Inflammatory Mediators in Biofilm Samples and Clinical Association in Multiple Sclerosis Patients in Remission-A Pilot Study

Jakob Fehlhofer, Jutta Ries, Florian Tobias Nickel, Veit Rothhammer, Stefan Schwab, Marco Kesting, Mayte Buchbender
Life (Basel). 2024. doi: 10.3390/life14030367

Gut-Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond

Julia Zißler, Veit Rothhammer, Mathias Linnerbauer 
Cells. 2024. doi: 10.3390/cells13060497

Disease-associated astrocyte epigenetic memory promotes CNS pathology

Hong-Gyun Lee, Joseph M. Rone, Zhaorong Li, Camilo Faust Akl, Seung Won Shin, Joon-Hyuk Lee, Lucas E. Flausino, Florian Pernin, Chun-Cheih Chao, Kilian L. Kleemann, Lena Srun, Tomer Illouz, Federico Giovannoni, Marc Charabati, Liliana M. Sanmarco, Jessica E. Kenison, Gavin Piester, Stephanie E. J. Zandee, Jack P. Antel, Veit Rothhammer, Michael A. Wheeler, Alexandre Prat, Iain C. Clark & Francisco J. Quintana
Nature. 2024. doi: 10.1038/s41586-024-07187-5

The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology

Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter, Yanan Han, Thanos Tsaktanis, Emile Wogram, Maria Needhamsen, Lara Kular, Lisa Nagel, Julia Zissler, Marie Andert, Lisa Meszaros, Jannis Hanspach, Finnja Zuber, Ulrike J. Naumann, Martin Diebold, Michael A. Wheeler, Tobias Beyer, Lucy Nirschl, Ana Cirac, Frederik B. Laun, Claudia Günther, Jürgen Winkler, … Veit Rothhammer
Nature Immunology. 2024. doi: 10.1038/s41590-024-01756-6

Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients

Laura Krumm, Tatyana Pozner, Naime Zagha, Roland Coras, Philipp Arnold, Thanos Tsaktanis, Kathryn Scherpelz, Marie Y. Davis, Johanna Kaindl, Iris Stolzer, Patrick Süß, Mukhran Khundadze, Christian A. Hübner, Markus J. Riemenschneider, Jonathan Baets, Claudia Günther, Suman Jayadev, Veit Rothhammer, Florian Krach, Jürgen Winkler, Beate Winner & Martin Regensburger
Acta Neuropathol. 2024. doi: 10.1007/s00401-023-02675-w

2023

The role of midkine in health and disease

Emely Elisa Neumaier, Veit Rothhammer, Mathias Linnerbauer
Front Immunol . 2023. doi: 10.3389/fimmu.2023.1310094

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

Mathias Linnerbauer #, Tobias Beyer #, Lucy Nirschl, Daniel Farrenkopf, Lena Lößlein, Oliver Vandrey, Anne Peter, Thanos Tsaktanis, Hania Kebir, David Laplaud, Rupert Oellinger, Thomas Engleitner, Jorge Ivan Alvarez, Roland Rad, Thomas Korn, Bernhard Hemmer, Francisco J Quintana, Veit Rothhammer
Nature Communications. 2023. doi: 10.1038/s41467-023-40982-8

Impact of Microbiome-Brain Communication on Neuroinflammation and Neurodegeneration

Iris Stolzer, Eveline Scherer, Patrick Süß, Veit Rothhammer, Beate Winner, Markus F Neurath, Claudia Günther
Int J Mol Sci . 2023. doi: 10.3390/ijms241914925

Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation

Sebastian Zundler, Claudia Günther, Andreas E Kremer, Mario M Zaiss, Veit Rothhammer, Markus F Neurath
Nat Rev Gastroenterol Hepatol . 2023. doi: 10.1038/s41575-022-00663-1

Association between cognition and gait in multiple sclerosis: A smartphone-based longitudinal analysis

Alzhraa A Ibrahim, Werner Adler, Heiko Gaßner, Veit Rothhammer, Felix Kluge, Bjoern M Eskofier
Int J Med Inform. 2023. doi: 10.1016/j.ijmedinf.2023.105145

Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

Liliana M Sanmarco, Joseph M Rone, Carolina M Polonio, Gonzalo Fernandez Lahore, Federico Giovannoni, Kylynne Ferrara, Cristina Gutierrez-Vazquez, Ning Li, Anna Sokolovska, Agustin Plasencia, Camilo Faust Akl, Payal Nanda, Evelin S Heck, Zhaorong Li, Hong-Gyun Lee, Chun-Cheih Chao, Claudia M Rejano-Gordillo, Pedro H Fonseca-Castro, Tomer Illouz, Mathias Linnerbauer, Jessica E Kenison, Rocky M Barilla, Daniel Farrenkopf, Nikolas A Stevens, Gavin Piester, Elizabeth N Chung, Lucas Dailey, Vijay K Kuchroo, David Hava, Michael A Wheeler, Clary Clish, Roni Nowarski, Eduardo Balsa, Jose M Lora, Francisco J Quintana
Nature. 2023. doi: 10.1038/s41586-023-06409-6

Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis

Pia Sinner, Katrin Peckert-Maier, Hashem Mohammadian, Christine Kuhnt, Christina Draßner, Vasiliki Panagiotakopoulou, Simon Rauber, Mathias Linnerbauer, Zhana Haimon, Dmytro Royzman, Deborah Kronenberg-Versteeg, Andreas Ramming, Alexander Steinkasserer, Andreas B Wild
Nature Communications. 2023. doi: 10.1038/s41467-023-40370-2

Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing-remitting multiple sclerosis

Thanos Tsaktanis #, Mathias Linnerbauer, Lena Lößlein, Daniel Farrenkopf, Oliver Vandrey, Anne Peter, Ana Cirac, Tobias Beyer, Lucy Nirschl, Verena Grummel, Mark Mühlau, Matthias Bussas, Bernhard Hemmer, Francisco J Quintana, Veit Rothhammer
Brain Communications. 2023. doi: 10.1093/braincomms/fcad206

Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy

Jochen A Sembill, Christoph Lusse, Mathias Linnerbauer, Maximilian I Sprügel, Anne Mrochen, Michael Knott, Tobias Engelhorn, Manuel Alexander Schmidt, Arnd Doerfler, Timo Jan Oberstein, Juan Manuel Maler, Johannes Kornhuber, Piotr Lewczuk, Veit Rothhammer, Stefan Schwab, Joji B Kuramatsu
Brain Communications. 2023. doi: 10.1093/braincomms/fcad159

Droplet-based forward genetic screening of astrocyte-microglia cross-talk

Michael A Wheeler #, Iain C Clark #, Hong-Gyun Lee #, Zhaorong Li, Mathias Linnerbauer, Joseph M Rone, Manon Blain, Camilo Faust Akl, Gavin Piester, Federico Giovannoni, Marc Charabati, Joon-Hyuk Lee, Yoon-Chul Kye, Joshua Choi, Liliana M Sanmarco, Lena Srun, Elizabeth N Chung, Lucas E Flausino, Brian M Andersen, Veit Rothhammer, Hiroshi Yano, Tomer Illouz, Stephanie E J Zandee, Carolin Daniel, David Artis, Marco Prinz, Adam R Abate, Vijay K Kuchroo, Jack P Antel, Alexandre Prat, Francisco J Quintana
Science. 2023. doi: 10.1126/science.abq4822

2022

Identification of environmental factors that promote intestinal inflammation

Liliana M. Sanmarco, Chun-Cheih Chao, Yu-Chao Wang, Jessica E. Kenison, Zhaorong Li, Joseph M. Rone, Claudia M. Rejano-Gordillo, Carolina M. Polonio, Cristina Gutierrez-Vazquez, Gavin Piester, Agustin Plasencia, Lucinda Li, Federico Giovannoni, Hong-Gyun Lee, Camilo Faust Akl, Michael A. Wheeler, Ivan Mascanfroni, Merja Jaronen, Moneera Alsuwailm, Patrick Hewson, Ada Yeste, Brian M. Andersen, Diana G. Franks, Chien-Jung Huang, Millicent Ekwudo, Emily C. Tjon, Veit Rothhammer, Maisa Takenaka, Kalil Alves de Lima, Mathias Linnerbauer, Lydia Guo, Ruxandra Covacu, Hugo Queva, Pedro Henrique Fonseca-Castro, Maha Al Bladi, Laura M. Cox, Kevin J. Hodgetts, Mark E. Hahn, Alexander Mildner, Joshua Korzenik, Russ Hauser, Scott B. Snapper & Francisco J. Quintana
Nature. 2022. doi: 10.1038/s41586-022-05308-6

An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research

Rachel A. Kline, Lena Lößlein, Dominic Kurian, Judit Aguilar Martí, Samantha L. Eaton, Felipe A. Court , Thomas H. Gillingwater, and Thomas M. Wishart
Cells. 2022. https://doi.org/10.3390/cells11172653

Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation

Sebastian Zundler, Claudia Günther, Andreas E. Kremer, Mario M. Zaiss, Veit Rothhammer & Markus F. Neurath
Nat Rev Gastroenterol Hepatol. 2022. doi.org/10.1038/s41575-022-00663-1

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis

Mattias Bronge, Klara Asplund Högelin, Olivia G Thomas, Sabrina Ruhrmann, Claudia Carvalho-Queiroz, Ola B Nilsson, Andreas Kaiser, Manuel Zeitelhofer, Erik Holmgren, Mathias Linnerbauer, …, Tomas Olsson and Hans Grönlund
Sci Adv. 2022. DOI: 10.1126/sciadv.abn1823

Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation

Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Thanos Tsaktanis, Alexander Beer, Ulrike J. Naumann, Franziska Panier, Tobias Beyer, Lucy Nirschl, Joji B. Kuramatsu, Jürgen Winkler, Francisco J. Quintana, and Veit Rothhammer
JCI Insight. 2022. 10.1172/jci.insight.154824

Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation

Mathias Linnerbauer, Lena Lößlein, Daniel Farrenkopf, Oliver Vandrey, Thanos Tsaktanis, Ulrike Naumann and Veit Rothhammer
Frontiers in Immunology. 2022. https://doi.org/10.3389/fimmu.2021.800128

2021

The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis

Ana Cirac, Thanos Tsaktanis, Tobias Beyer, Mathias Linnerbauer, Till Andlauer, Verena Grummel, Lucy Nirschl, Lena Loesslein, Francisco J. Quintana, Bernhard Hemmer, Veit Rothhammer
Neurology Neuroimmunology & Neuroinflammation 2021. DOI: https://doi.org/10.1212/NXI.0000000000001043

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Iain C. Clark*, Cristina Gutiérrez-Vázquez*, Michael A. Wheeler*, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M. Sanmarco, Lydia Guo, Manon Blain, Stephanie E. J. Zandee, Chun-Cheih Chao, Katelyn V. Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W. Shultis, Yasmin Salem, Emily C. Tjon, Pedro H. Fonseca-Castro, Davis M. Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R. Abate9, Douglas L. Rosene, Kevin J. Hodgetts, Marco Prinz, Jack P. Antel, Alexandre Prat, Francisco J. Quintana
Science 2021. DOI: 10.1126/science.abf1230

Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline

Janos Groh, Konrad Knöpper, Panagiota Arampatzi, Xidi Yuan, Lena Lößlein, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller & Rudolf Martini
Nat Aging 2021. https://doi.org/10.1038/s43587-021-00049-z

Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS

Veit Rothhammer, Jessica E Kenison, Zahorong Li, Emily Tjon, Maisa C Takenaka, Chun-Cheih Chao, Kalil Alves de Lima, Davis M Borucki, Joel Kaye, Francisco J Quintana
Neurol Neuroimmunol Neuroinflamm 2021. DOI: 10.1212/NXI.0000000000000946

A cell-based drug delivery platform for treating central nervous system inflammation

Oren Levy*, Veit Rothhammer*, Ivan Mascanfroni, Zhixiang Tong, Rui Kuai, Michael De Biasio, Qingping Wang, Tahir Majid, Christelle Perrault, Ada Yeste, Jessica E. Kenison, Helia Safaee, Juliet Musabeyezu, Martina Heinelt, Yuka Milton, Heidi Kuang, Haoyue Lan, William Siders, Marie-Christine Multon, Jonathan Rothblatt, Salam Massadeh, Manal Alaamery, Ali H. Alhasan, Francisco J. Quintana & Jeffrey M. Karp
Journal of Molecular Medicine 2021. https://doi.org/10.1007/s00109-020-02003-9

Gut-licensed IFNy+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

Liliana M. Sanmarco*, Michael A. Wheeler*, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A. Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V. Batterman, Giulia Scalisi, Stephanie E. J. Zandee, Evelyn S. Heck, Moneera Alsuwailm, Douglas L. Rosene, Burkhard Becher, Isaac M. Chiu, Alexandre Prat & Francisco J. Quintana
Nature 2021. https://www.nature.com/articles/s41586-020-03116-4

2020

Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS

Thanos Tsaktanis, Tobias Beyer, Lucy Nirschl, Mathias Linnerbauer, Verena Grummel, Mathias Bussas, Emily Tjon, Mark Mühlau, Thomas Korn, Bernhard Hemmer, Francisco J. Quintana, Veit Rothhammer
Neurology Neuroimmunology & Neuroinflammation 2020. https://doi.org/10.1212/NXI.0000000000000933

Protective functions of reactive astrocytes following central nervous system insult

Mathias Linnerbauer, Veit Rothhammer
Front. Immunol. 2020. doi: 10.3389/fimmu.2020.573256

Astrocyte Crosstalk in CNS Inflammation

Mathias Linnerbauer, Michael Wheeler, Francisco J. Quintana
Neuron, 2020. https://doi.org/10.1016/j.neuron.2020.08.012

AHR is a Zika virus host factor and a candidate target for antiviral therapy

Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F Torti, Michael A Wheeler, Zhaorong Li, Leonardo Romorini, María S Rodriguez Varela, Veit Rothhammer, Andreia Barroso, Emily C Tjon, Liliana M Sanmarco, Maisa C Takenaka, Seyed Mohamad Sadegh Modaresi, Cristina Gutiérrez-Vázquez, Nágela Ghabdan Zanluqui, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Zhongyan Wang, Elsa B Damonte, David Sherr, Lee Gehrke, Jean Pierre Schatzmann Peron, Cybele C Garcia, Francisco J Quintana.
Nat Neurosci. 2020;23(8):939-951. doi:10.1038/s41593-020-0664-0

2019

The Aryl Hydrocarbon Receptor: An Environmental Sensor Integrating Immune Responses in Health and Disease

Rothhammer V, Quintana FJ. 
Nat Rev Immunol. 2019;19(3):184‐197. doi:10.1038/s41577-019-0125-8

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chao CC, Gutiérrez-Vázquez C, Rothhammer V, et al. 
Cell. 2019;179(7):1483‐1498.e22. doi:10.1016/j.cell.2019.11.016

IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis

Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, et al.
J Immunol. 2019;203(4):888‐898. doi:10.4049/jimmunol.1900400

2018

Microglial control of astrocytes in response to microbial metabolites

Rothammer, V., Borucki, D.M., Tjon, E.C. et al. 
Nature 557, 724–728 (2018). doi:10.1038/s41586-018-0119-x

Detection of Aryl Hydrocarbon Receptor Agonists in Human Samples

Rothhammer V, Borucki DM, Kenison JE, et al.
Sci Rep. 2018;8(1):4970. Published 2018 Mar 21. doi:10.1038/s41598-018-23323-4

2017

Sphingosine 1-phosphate Receptor Modulation Suppresses Pathogenic Astrocyte Activation and Chronic Progressive CNS Inflammation

Rothhammer V, Kenison JE, Tjon E, et al.
Proc Natl Acad Sci U S A. 2017;114(8):2012‐2017. doi:10.1073/pnas.1615413114

Dynamic Regulation of Serum Aryl Hydrocarbon Receptor Agonists in MS

Rothhammer V, Borucki DM, Garcia Sanchez MI, et al.
Neurol Neuroimmunol Neuroinflamm. 2017;4(4):e359. Published 2017 Jun 16. doi:10.1212/NXI.0000000000000359

2016

Type I Interferons and Microbial Metabolites of Tryptophan Modulate Astrocyte Activity and Central Nervous System Inflammation via the Aryl Hydrocarbon Receptor

Rothhammer V, Mascanfroni ID, Bunse L, et al.
Nat Med. 2016;22(6):586‐597. doi:10.1038/nm.4106

Environmental Control of Autoimmune Inflammation in the Central Nervous System

Rothhammer V, Quintana FJ.
Curr Opin Immunol. 2016;43:46‐53. doi:10.1016/j.coi.2016.09.002

2015

Control of Autoimmune CNS Inflammation by Astrocytes

Rothhammer V, Quintana FJ.
Semin Immunopathol. 2015;37(6):625‐638. doi:10.1007/s00281-015-0515-3

Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)

Tsaktanis T, Kremling H, Pavšič M, et al.
J Biol Chem. 2015;290(40):24574‐24591. doi:10.1074/jbc.M115.662700